Blood plasma from patients is a powerful resource for diagnosing infectious disease due to\nit having many genetic materials as well as being relatively easy to obtain. Thus, various biosensors\nhave been investigated for diagnosing diseases in blood plasma. However, there are no optimized and\nvalidated sensors for clinical use due to the low sensitivity, complexity, and diffculties of removing\nthe inhibitors from plasma samples. In this study, we described a silicon microring resonator sensor\nused to detect Coxiella burnetii from the blood plasma of Q-fever patients in a label-free, real-time\nmanner. Q-fever is an infectious disease caused by Coxiella burnetii via direct contact or inhalation\naerosols. We validated this biosensor in the blood plasma of 35 clinical samples (including 16 Q\nfever samples infected with Coxiella burnetii and 19 samples infected with other febrile diseases.\nThe biosensors are capable of rapid (10 min), highly sensitive (87.5%), and specific (89.5%) detection\nin plasma samples compared to the use of the conventional method.
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